Skin Disorders Associated with Paraben Exposure: A Comprehensive Review Parabens, a class of synthetic preservatives widely used in cosmetics, pharmaceuticals, and personal care products since the 1950s, have been the subject of extensive research due to their potential cutaneous and systemic health effects. While their primary function is to prevent microbial growth and extend product shelf life, concerns about their role in skin disorders have persisted. This review synthesizes current evidence on parabens’ dermatological impacts, focusing on allergic contact dermatitis, skin irritation, exacerbation of pre-existing conditions, and secondary complications. Key findings indicate that while paraben-induced allergic reactions are rare (0.9–2% incidence), they disproportionately affect individuals with compromised skin barriers. Furthermore, emerging data suggest parabens may contribute to premature skin aging through keratinocyte alterations. Allergic Contact Dermatitis (ACD) Pathogenesis and Clinical Presentation Allergic contact dermatitis to parabens manifests as a delayed-type hypersensitivity reaction, characterized by erythema, edema, papules, vesicles, and pruritus at the site of exposure[2][9][11]. The mechanism involves haptenization, where paraben molecules bind to skin proteins, forming immunogenic complexes that activate T-cell-mediated responses[11]. Notably, the **”Paraben Paradox”** describes the phenomenon where reactions predominantly occur on damaged or eczematous skin rather than intact epidermis[4][11]. This is attributed to enhanced percutaneous absorption […]